Roads lead to the northeast from several directions.
From Akureyri, Road 1 takes you east to Þingeyjarsýsla and onwards up to Mývatn. Once in the Northeast, road 85 follows the coast all the way from Skjalfandi to Bakkaflói bay.
Air Iceland offers frequent flights from Reykjavík to Akureyri and also flies to Þórshöfn. Information and booking can be found online at their website.